|
KMID : 1146520140150010001
|
|
Journal of the Society of Stroke on Korean Medicine
2014 Volume.15 No. 1 p.1 ~ p.12
|
|
|
Effects of Ephedra Herba Hexane Fraction on Lipid Metabolism in Hyperlipidemic Mice
|
|
Kim Kyung-Min
Kim Young-Kyun
Shin Gil-Cho
|
|
|
Abstract
|
|
|
Objectives : This study was designed to investigate the effects of Ephedra Herba hexane fraction on lipid levels in serum and lipid accumulation in liver tissue in Hyperlipidemic mice.
Methods: Hyperlipidemia was induced by providing high fat diet for 4 weeks. Normal group was provided with normal diet. CTL groupwas provided with high fat diet. Ephedra Herba hexane fraction group was provieded with high fat diet and administered orally in the concentration of 1.5mg/kg body weight/day for 2 weeks. In this experiment, effects on total cholesterol, HDL-cholesterol, triglyceride, AST, ALT, fasting blood glucose in serum were measured. In addition histopathological changes in liver tissue were also observed.
Results : Ephedra Herba hexane fraction did not affects weight gain, serum AST and ALT in hyperlipidemic mice. Oral administration of Ephedra Herba hexane fraction lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. In addition, Ephedra Herba hexane fraction group showed downward tendency of lipid accumulation compared with CTL group. Finally, administration of Ephedra Herba hexane fraction lowered fasting blood glucose significantly. And Ephedra Herba hexane fraction also ameliorates anti-oxidative stress systems in internal organs which play key role in disease prevention.
Conclusion : These results suggest that Ephedra Herba hexane fraction can prevent lipid accumulation in liver tissue through regulation of dyslipidemia and hyperglycaemia.
|
|
|
KEYWORD
|
|
|
Ephedra Herba(Mahwang), Hexane fraction, Dyslipidemia, Cholesterol, Triglyceride
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|